当前位置:仪器网 > 产品中心 > 生命科学仪器及设备>细胞生物学仪器>细胞分析(细胞成像、流式细胞、能量代谢)>13601 AAT Bioquest Fluorimetric Renin Ass...
返回产品中心>蛋白去乙酰化酶(histone deacetylase,HDAC)是一类蛋白酶,对染色体的结构修饰和基因表达调控发挥着重要的作用。在癌细胞中,HDAC的过度表达导致乙酰化作用的增强,通过恢复组蛋白正电荷, 从而增加DNA与组蛋白之间的引力, 使松弛的核小体变得十分紧密, 不利于特定基因的表达, 包括一些肿瘤抑制基因。
产品描述:
蛋白去乙酰化酶(histone deacetylase,HDAC)是一类蛋白酶,对染色体的结构修饰和基因表达调控发挥着重要的作用。在癌细胞中,HDAC的过度表达导致乙酰化作用的增强,通过恢复组蛋白正电荷, 从而增加DNA与组蛋白之间的引力, 使松弛的核小体变得十分紧密, 不利于特定基因的表达, 包括一些肿瘤抑制基因。组蛋白去乙酰化酶抑制剂(histone deacetylase inhibitors,HDACi)则可通过提高染色质特定区域组蛋白乙酰化,从而调控细胞凋亡及分化相关蛋白的表达和稳定性,诱导细胞凋亡及分化,成为一类新的抗肿瘤药物。
产品性能:
Amplite HDAC检测试剂盒提供了一种快速、便捷、灵敏的方法来检测HDAC的活性。我们的HDAC绿色底物是一种非肽类复合物,它比其它基于肽类的HDAC底物更加稳定。我们的试剂盒可用于检测细胞裂解液中HDAC的活性,也可以与配合抽提物或纯化的酶应用于体外抑制剂的筛选。HDAC Green绿色荧光底物的长波长发射光合高激发系数,这使其在检测中不会引起很大的干扰。HDAC活性的测定,通过检测490nm处激发光和520nm处发射光的绿色荧光增强来实现。
英文注释:
Renin is an enzyme that participates in the body's renin-angiotensin system (RAS) that mediates extracellular volume and arterial vasoconstriction. It regulates blood pressure and electrolyte homoeostasis. Angiotensin II constricts blood vessels leading to increased blood pressure. It also increases the secretion of ADH and aldosterone, and stimulates the hypothalamus to activate the thirst reflex. An over-active renin-angiotension system leads to vasoconstriction and retention of sodium and water. Renin has been identified to be an attractive target for the treatment of hypertension. The Amplite Renin Assay Kit provides a convenient assay for high throughput screening of renin inhibitors and renin activity using our proprietary Tide Fluor 3 (TF3)/Tide Quencher 3 (TQ3) fluorescence resonance energy transfer (FRET) peptide. In the FRET peptide, the fluorescence of TF3 is quenched by TQ3. Upon cleavage into two separate fragments by renin, the fluorescence of TF3 is recovered, and the fluorescent signal can be easily monitored by a fluorescence microplate reader at Ex/Em = 540/590 nm. This assay is about fifty fold more sensitive than an EDANS/DABCYL-based assay. With the Amplite Renin Assay Kit, we have detected as little as 1ng renin in a 100 reaction volume.
其他产品:
产品名称 | 货号 | 规格 |
6-(4,6-二氯三嗪基)氨基荧光素] | 211 | 5 mg |
AMC[7-氨基-4-甲基香豆素] *荧光参照标准* | 051 | 1g |
AMC[7-氨基-4甲基香豆素]*标记多肽验证* | 052 | 5g |
AMC【7-氨基-4甲基香豆素]]*标记多肽验证* | 053 | 25g |
AFC【7-氨基-4-三氟甲基香豆素】*荧光参照标准* | 056 | 1g |
AFC【7-氨基-4-三氟甲基香豆素】*标记多肽验证* | 057 | 5g |
AFC【7-氨基-4-三氟甲基香豆素】*标记多肽验证* | 058 | 25g |
罗丹明110*荧光参照标准* 13558-31-1 | 86 | 1g |
5-6-羧基荧光素混合物 72088-94-9 | 100 | 1g |
5-6-羧基荧光素验证肽和寡核苷酸标记 | 101 | 10g |
5-6-羧基荧光素验证肽和寡核苷酸标记 | 102 | 25g |
5-羧基荧光素CAS号76823-03-5 | 103 | 100 mg |
5-羧基荧光素76823-03-5*验证肽和寡核苷酸标记* | 104 | 1g |
5-羧基荧光素*验证肽和寡核苷酸标记* | 105 | 5 g |
7-羟基香豆素-3-乙酸 779-27-1 | 550 | 250 mg |
7-羟基香豆素-3-乙酸,琥珀酰亚胺 7-Hydroxycoumarin-3-carboxylic acid… | 551 | 50 mg |
7-Hydroxycoumarin-4-acetic 胺酸 | 552 | 100 mg |
7-Hydroxycoumarin-4-acetic 胺酸,琥珀酰SE | 553 | 25 mg |
7-羟基-4-甲基香豆素-3-乙酸 | 554 | 100 mg |
7-羟基-4-甲基香豆素-3-乙酸,琥珀酰亚胺酯 | 556 | 25 mg |
MCA 7-甲氧基香豆素-4-乙酸 CAS:62935-72-2 | 557 | 1g |
7-甲氧基香豆素-4-乙酸, 琥珀酰亚胺酯 | 558 | 25 mg |
7-甲氧基香豆素-3-羧酸 20300-59-8 | 560 | 1g |
7-甲氧基香豆素-3-羧酸 20300-59-8 | 561 | 5 g |
7-甲氧基香豆素-3-羧酸,琥珀酰亚胺酯 150321-92-9 | 563 | 100 mg |
5(6)-FAM,SE[5(6)-羧基荧光素琥珀酰亚胺脂]*同分异构体混合物* | 110 | 25 mg |
5(6)-FAM,SE[5(6)-羧基荧光素琥珀酰亚胺脂]*验证肽和寡核苷酸标 | 111 | 100 mg |
5(6)-FAM,SE[5(6)-羧基荧光素琥珀酰亚胺脂]*验证肽和寡核苷酸标 | 112 | 1g |
5-FAM,SE[5-羧基荧光素琥珀酰亚胺脂] *单体* | 113 | 10 mg |
5-FAM, SE[5-羧基荧光素琥珀酰亚胺脂]*验证多肽标记验证* | 114 | 100 mg |
5-FAM, SE[5-羧基荧光素琥珀酰亚胺脂]*验证多肽标记验证* | 115 | 1g |
5-FITC [异硫氰酸荧光素] *超纯级* | 120 | 100 mg |
5-FITC [异硫氰酸荧光素] *超纯级* | 121 | 1g |
5-FITC [异硫氰酸荧光素] *超纯级* | 122 | 10g |
5(6)-FAM 乙二胺 | 123 | 100 mg |
5-FITC 尸胺 | 129 | 100 mg |
荧光素-5-马来酰亚胺 | 130 | 25 mg |
5-IAF[5-吲哚乙酰氨基荧光素] 5-IAF [5-Iodoacetamidofluorescei | 222 | 25 mg |
Cyanine 3.5 amine [equivalent to Cy3.5® amine] | 139 | 1 mg |
5-羧基罗丹明110*单体* | 322 | 5 mg |
6-羧基罗丹明110*单体* | 323 | 5 mg |
5-(6)-羧基罗丹明6G*同分异构体混合物* | 330 | 25 mg |
5-羧基罗丹明6G*单体* | 331 | 10 mg |
6-羧基罗丹明6G*单体* | 332 | 10 mg |
[5-(6)-羧基罗丹明6G琥珀酰亚胺脂]*同分异构体混合物* 5(6)-CR6G | 340 | 10 mg |
5-CR6G, SE [5-羧基罗丹明6G琥珀酰] *单体* 209112-21-0 | 341 | 1 mg |
5-CR6G, SE [5-羧基罗丹明6G琥珀酰] *单体* | 345 | 5 mg |
5, (6)-羧基四甲基罗丹明*同分异构体混合物* | 360 | 100 mg |
5, (6)-羧基四甲基罗丹明*验证肽和寡核苷酸标记* | 361 | 1g |
5, (6)-羧基四甲基罗丹明*验证肽和寡核苷酸标记* | 362 | 5 g |
*您想获取产品的资料:
个人信息: