脊髓打击仪

脊髓损伤撞击器(MASCIS Impactor,NYU Impactor)是用来为大小鼠的脊椎施加可重复的标准撞击力的设备。

此型号的脊髓损伤撞击器已经开发应用超过十年它是啮齿类动物脊髓损伤模型的一部分有超过100个实验室在使用它。有很多关于脊髓损伤研究文献使用的是MASCIS撞击器。很多相关仪器的建议操作程序是源自于Multicenter Animal Spinal Cord Injury Study(MASCIS)模型和实际工作经验。

现有MASCIS撞击器是它的第三代产品与以前的产品相比已经有很多方面的改进提高。有两个型号的撞击器可供选择

基本版撞击器(The Rutgers Impactor,Model II型)仅进行撞击 不记录数据。电脑版撞击器(Model III型)既可以实现精准撞击还可以记录数据。

电脑版撞击器(Model III型)可以精确测量一个10克的小棒的运动情况这个小棒从12.5mm25mm50mm高处落到术后暴露的脊髓T9-10处。另外设备还可以测量撞击位置脊柱的运动。显示坠落小棒的轨迹并测量撞击速度（ImpV）脊髓压缩距离（Cd）脊髓压缩时间(Ct)脊髓压缩率(Cr)。这些撞击参数本身是相关的同时与其它的脊髓损伤数值如组织NaK浓度运动恢复locomotor recovery(BBB 评分)也是相关的。

大小鼠的撞击都需要一个固定系统(Clamping systems)。同时还需要一个CS-tie。

改良NYU型脊髓损伤打击仪型号为Model I I I主要特点如下

采用10克重打击头对脊髓进行损伤打击

下落距离12.525.050mm可调

精确测量打击头的移动距离打击力度（ImpV）脊髓压缩距离（Cd）压缩时间(Ct)压缩率（Cr）等参数

打击仪尺寸43 cm high x 30 cm deep x 25cm wide重量5公斤

第三代产品包含了计算机和软件负责数据的采集工作

                   Model II型                                               Model III型

参考文献
1:Serial changes in bladder, locomotion, and levels of neurotrophic factors in rats with spinal cord contusion.

Hyun JK, Lee YI, Son YJ, Park JS.
Department of Rehabilitation Medicine, Dankook University, Cheonan, Korea. rhhyun@dankook.ac.kr

2:A re-assessment of minocycline as a neuroprotective agent in a rat spinal cord contusion model.

Pinzon A, Marcillo A, Quintana A, Stamler S, Bunge MB, Bramlett HM, Dietrich WD.
Brain Res. 2008 Dec 3;1243:146-51. Epub 2008 Sep 24.

3 :The role of cation-dependent chloride transporters in neuropathic pain following spinal cord injury.

Cramer SW, Baggott C, Cain J, Tilghman J, Allcock B, Miranpuri G, Rajpal S, Sun D, Resnick D.
Mol Pain. 2008 Sep 17;4:36.

4:Novel combination strategies to repair the injured mammalian spinal cord.

Bunge MB.
J Spinal Cord Med. 2008;31(3):262-9. Review.

5:A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury.

Pinzon A, Marcillo A, Pabon D, Bramlett HM, Bunge MB, Dietrich WD.
Exp Neurol. 2008 Sep;213(1):129-36. Epub 2008 Jul 14.

6: B1 and TRPV-1 receptor genes and their relationship to hyperalgesia following spinal cord injury.
DomBourian MG, Turner NA, Gerovac TA, Vemuganti R, Miranpuri GS, Türeyen K, Satriotomo I, Miletic V, Resnick DK.
Spine. 2006 Nov 15;31(24):2778-82.

7:Endothelial cell loss is not a major cause of neuronal and glial cell death following contusion injury of the   spinal cord.
Casella GT, Bunge MB, Wood PM.
Exp Neurol. 2006 Nov;202(1):8-20. Epub 2006 Jul 26.

8:Recovery of function following grafting of human bone marrow-derived stromal cells into the injured spinal cord.
Himes BT, Neuhuber B, Coleman C, Kushner R, Swanger SA, Kopen GC, Wagner J, Shumsky JS, Fischer I.
Neurorehabil Neural Repair. 2006 Jun;20(2):278-96.

9:Mechanical and cold allodynia in a rat spinal cord contusion model.
Yoon YW, Dong H, Arends JJ, Jacquin MF.
Somatosens Mot Res. 2004 Mar;21(1):25-31.

10:Spinal cord contusion models.
Young W.
Prog Brain Res. 2002;137:231-55. Review.

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