MICA抗体Anti-MICA抗体说明书  

Catalog Number : RS-0832R   

Quantity size :   0.1ml  （dilute with pH 7.4    0.01 M PBS or antibody diluent ）

Background: The MHC class I chain-related （MIC） proteins are related to the Major histocompatibility complex （MHC） class I proteins which are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells. The MHC class I chain-related （MIC） proteins are recognized by NKG2D, a receptor on NK and T cells, and promote anti-tumor activity. MICA, a member of the MIC family, is widely expressed on many tumors, and it is the MICA/NKG2D interaction that is thought to stimulate the anti-tumor reactivity by T lymphocytes. MICA is present in virtually every tissue except the nervous system, suggesting that MIC protein expression may only be one component of the anti-tumor activity of the immune system.

Function : Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.             

MICA抗体Anti-MICA抗体说明书  Specificity :   · anti-MICA is a mouse monoclonal antibody unconjugated

             · specific for MICA of pig

            · use for western blotting,elisa,immunoprecipitation and immunohistochemistry

            · Protein G affinity chromatography purification, purity :>95%

             · Isotype: IgG

             · mol wt: 43kDa

Application:    · Western blotting 1:100-500

               · Immunohistochemistry 1:100-500

               · ELISA 1:500-1000

               · Optimal working dilutions must be determined by the end user.

Storage:     Store at –20 ºC for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20ºC. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least two weeks at 2-4 ºC.

IMICA抗体Anti-MICA抗体说明书  mportant Note: This product as supplied is intended for research use only, not for use in human,therapeutic or diagnostic applications.